MPT Resource Center

Dose-ranging pharmacokinetics, safety, and efficacy of a 90-day intravaginal ring delivering islatravir in pigtail macaques

Intravaginal rings (IVRs) are attractive user-controlled delivery systems that can achieve sustained release of compounds for several weeks. We modeled in macaques a three-dimensional (3D)–printed IVR delivering the investigational nucleoside reverse transcriptase translocator inhibitor islatravir (ISL). Three IVRs with 15, 30, or 60 milligrams of ISL were used in 30-day pharmacokinetic and safety studies followed […]

Srinivasan, P., King, J. L., Zhang, J., Young, I. C., Little, D., Cottrell, M. L., Sykes, C., Schauer, A. P., Mitchell, J., Kashuba, A. D. M., García-Lerma, J. G., Benhabbour, S. R., Smith, J. M. Visit Resource August 2026

A snapshot of how U.S. funding cuts impacted HIV care in one county of Kenya: a qualitative case study

Sedlander, E., Lawson, K., Wairimu, N., Werner, K., Mutai, S., Mwai, D., Gandhi, M., Ngure, K. Visit Resource July 2026

Beyond Myths: Addressing Real Concerns About Contraception and Future Fertility

Begg, L., Owolabi, O., Polis, C. B. June 2026

‘ … they just take one pill, so it is easy to use, more convenient … ’: South African health care provider perspectives on a Dual Prevention Pill

The Dual Prevention Pill (DPP) is a daily oral pill containing oral pre-exposure prophylaxis (PrEP) for protection against HIV and a combined oral contraceptive (COC) for the prevention of unintended pregnancy, currently under development. However, little is known about healthcare providers’ (HCPs) perspectives on this potential new multipurpose prevention technology (MPT). A more granular understanding […]

Mathur, S., Tenza, S., Begg, L., Mampuru, L., Bruce, I. V., Moji, M., Ndlovu, N., Reddy, K., Palanee-Phillips, T., Friedland, B. A. Visit Resource May 2026

Intravenous and Subcutaneous Pharmacokinetic Modeling to Support the Development of Long-Acting Multipurpose Prevention Technology for HIV and Pregnancy

Engel, N., Oliveira, D. April 2026

Recommendations for Expanding Regulatory Agility and Evidentiary Integrity in Developing Treatments for Rare Diseases

Reagan-Udall Foundation for the Food and Drug Administration (FDA) April 2026

How have Biomedical Engineering Advancements Shaped the Development of Contraceptive Devices from the 19th Century to the Present?

Khokhar, A.S. March 2026

Safety, acceptability, and adherence to dapivirine vaginal ring and oral pre-exposure prophylaxis for HIV prevention in the second trimester of pregnancy: a multicountry, open-label, phase 3b randomised trial

Mhlanga, F.G., Szydlo, D.W., Mayo, A.J., Bunge, K., Fairlie, L., Nakabiito, C., Musara, P., Mgodi, N.M., Dadabhai, S., Scheckter, R., Anderson, P.L., Marzinke, M.A., Chappell, C., Gadama, L.A., Richardson, B.A., Piper, J.M., Hillier, S.L. March 2026

Multipurpose vaginal rings: preferences from a national discrete choice experiment survey among US women

Gottert, A., Mathur, S., Friedland, B.A., Abuya, T., Bruce, I.V., Burnett-Zieman, B., Plagianos, M.G., Shetty, S., Sales, J.M., Haddad, L.B. February 2026

Strengthening nationally led approaches to new product introduction for HIV prevention

Subedar, H., Ncube, N.B.Q., Kadama, H., Matanje, B., Kamya, M.R., Mugambi, C., Mudiope, P., Ajose, O., Jenkins, S.Y., Roxo, U.C., Pérez Casas, C., Warren, M., Cameron, A., Ismail, A., Odek, J., Gunda, A., Mulenga, L., Ozituosauka, W., Hamm Rush, S., Luba, M., Hoege, D., Sakala, M., Igbinosun, B.O., Burry, J., Allinder, S.M., Holmes, C.B. January 2026

Sexual and reproductive health in disasters: A systematic review of digital health and multipurpose prevention

Dewantiningrum, J., Andonotopo, W., Pramono, M.B.A., Prabowo, W., Bachnas, M.A., Sanjaya, I.N.H., Wiradnyana, A.A.G.P., Darmawan, E., Akbar, M.I.A., Gumilar, K.E., Aldiansyah, D., Andanaputra, W.E.K., Suryawan, A., Putra, R.A., Stanojeviv, M. January 2026

HIV prevention for young African women is about choice

Stewart, J., Heffron, R., Celum, C. January 2026

The Current and Future Impact of WHO Guidance on Global HIV Pre-Exposure Prophylaxis Programs: A Narrative Review

Mishriky, F., Chan, P.A. January 2026

Bridging HIV prevention and sexual reproductive health services in the context of multi-method PrEP: a qualitative study exploring provider perceptions in South Africa

Musvipwa, F.M., Dada, S., Cholo, F.A., Pleaner, M., Letsielo, M.J., Arries, S., Kutywayo, A., Martin, C.E., Mullick, S. January 2026

Uptake of dapivirine vaginal ring and oral pre-exposure prophylaxis among women accessing HIV prevention services in South Africa: a cohort study

Martin, C.E., Ramatsoma, H., Chidumwa, G., Nongena, P., Letsielo, M.J., Kutywayo, A., Koloane, N., Ncube, S., Mdluli, N., Nattey, C., Mullick, S. January 2026

Modern contraception utilization and associated factors among adolescent girls and young women (AGYW) who participated in the Namibia DREAMS program

Moyo, E., Melese, E., Mangwana, H., Takawira, S., Harases, B., Indongo, R., Moyo, P., Makurira Nyoni, N., Dzinamarira, T. December 2025

Artificial neural network guided optimization of tenofovir and Cyanovirin-N multipurpose preventive hydrogel formulation developed using the Box Behnken design model

Oyediran, K.O., Cardoso-Daodu, I.M., Bassey, P.O., Ogundemuren, D.A., Muhammed, R., Ojo, O.E., Amenaghawon, A.N., Azubuike, C.P., Agarwal, R., Haritha, K., Ilomunaya, M.O. December 2025

Advances in drug-releasing vaginal rings

McCoy, C.F., Zhao, X., Shen, X., Bashi, Y.H.D., Murphy, D.J., Boyd, P., Malcolm, R.K. November 2025

A Dual Prevention Pill for HIV & Pregnancy Prevention: A Pilot Study Among Adolescent Girls and Young Women in Zimbabwe

Mgodi, N.M., Burnett-Zieman, J.B., Murombedzi, C., Dandadzi, A., Gatsi, V., Musara, P., Matimbira, S., Mavemwa, G., Jambaya, J., Chidemo, T., Plagianos, M., Haddad, L.B., Bruce, I.V., Mathur, S., Friedland, B.A. November 2025

Beyond the pill: contextual effects of community-based PrEP delivery on pregnancy risk among FSWs in Cameroon – a propensity score-matched analysis

Noah, J.P.Y.A., Ndongo, F.A., Ndié, J., Bonyohe, M.G., Dongmo, R.K., Komokcheua, R.B., Tabala, F.N., Ateudjieu, J., Bissek, A.C.Z.K. November 2025

Next Generation 3D Printed Multipurpose Intravaginal Ring For Sustained Co-Delivery of Antiretroviral Drugs and A Contraceptive Hormone

Dahl, D.K., Janusziewicz, R., Shrivastava, R., Maturavongsadit, P., Chan, E., Montgomery, S.A., Benhabbour, S.R. November 2025

Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them

Herron, T.J., Brüning-Richardson, A., Gough, J.E., Miller, A.F., Pilkington, G.J., Greenman, J., Speirs, V., Wu, J.C. October 2025

Tenofovir and levonorgestrel vaginal MPT film developed via quality by design approach (drug release and safety evaluation in an animal model)

Muhammad, R., Bassey, P. O., Nwaneri, S. C., Cardoso-Daodu, I. M., Oladosu, A. A., Oyediran, K. O., Ilomuanya, M. O. September 2025

“…this could be a noble idea and a game changer.” The potential of a dual prevention pill for HIV and pregnancy prevention among adolescent girls and young women in Zimbabwe.

Dandadzi, A., Mathur, S., Musara, P., Bruce, I., Begg, L., Sedze, N. T., Mutero, P., Mgodi, N. M., Friedland, B. A. August 2025

Predictors Of Dual Protection Use Based On Information-Motivation-Behavior Skill Model Among Female University Students: A Cross-Sectional Study

Feyisa, B. N., Debelew, G. T., Koricha, Z. B. August 2025

Exploring the Safety and Compatibility of a Ready-to-Use Vaginal Film Vehicle for Drug Delivery: A Clinical Assessment

Marianni, B., Silva, C. C. V., Koulouridas, S., Polonini, H. August 2025

Innovative Multilayered Electrospun Fiber Systems for Dual-Action HIV Prophylaxis and Non-hormonal Contraception

Ogundemuren, D. A., Bassey, P.-O. O., Oyediran, K. O., Nmesoma, O. G., Tsamos, D., Tsamis, A., Tsouknidas, A. E. June 2025

Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects

Sanchez Armengol, E., Veider, F., Millotti, G., Kali, G., Bernkop-Schnürch, A., Laffleur, F. June 2025

Vaginally-delivered fast-dissolving antibody tablets (FDAT) for on-demand non-hormonal contraception and multi-purpose protection

Kushiro, K., Hammers, S., Zhu, Y., Flowers, H. B., Dawson, L., Panjwani, A., Schaefer, A., Quan, D., Gibb, K., McSweeney, M., Cone, R., Moench, T., Vincent, K. L., Lai, S. K. June 2025

Frontiers in Reproductive Health: Regulatory Pathways and Challenges in MPT Development

Donaldson, L., Schaefer, R., Alhakimi, S., Akulu, R., Palanee-Phillips, T., Young Holt B., Miller, V. May 2025

A multipurpose silicone elastomer vaginal ring releasing dapivirine and Cu2+/Zn2+ ions for HIV prevention and non-hormonal contraception

Shen, X., Boyd, P., Dallal Bashi, Y.H., McCoy, C.F., Zhao, X., Malcolm, R.K. April 2025

Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis

Vodstrcil, L.A., Plummer, E.L., Fairley, C.K., Hocking, J.S., Law, M.G., Petoumenos, K., Bateson, D., Murray, G.L., Donovan, B., Chow, E.P.F., Chen, M.Y., Kaldor, J., Bradshaw, C.S. March 2025

Acceptability of an annual tenofovir alafenamide implant for HIV prevention in South African women: findings from the CAPRISA 018 Phase I clinical trial

Gengiah, T.N., Heck, C.J., Lewis, L., Mansoor, L.E., Harkoo, I., Myeni, N., Baum, M.M., Moss, J.A., Rooney, J.F., Hankins, C., Pozzetto, B., Abdool Karim, S.S., Abdool Karim, Q. February 2025

Advancing Health Solutions: Practical Considerations for Multipurpose Prevention Technologies in Sub-Saharan Africa’s Fight Against HIV, Sexually Transmitted Infections, and Unintended Pregnancies

Mgodi, N.M., Murombedzi, C., Murewanhema, G., Moyo, E., Dzinamarira, T. January 2025

Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology development

Friedland, B.A., Gundacker, H., Achilles, S.L., Chen, B.A., Hoesley, C., Richardson, B.A., Kelly, C.W., Piper, J., Johnson, S., Devlin, B., Steytler, J., Kleinbeck, K., Dangi, B., Friend, C., Song, M., Mensch, B., van der Straten, A., Jacobson, C., Hendrix, C.W., Brown, J., Blithe, D., Hiller, S.L. January 2025

Formulation development of dual-compartment topical inserts combining tenofovir alafenamide and elvitegravir for flexible on-demand HIV prevention

Agrahari, V., Peet, M.M., Chandra, N., Ramalingam, P., Gupta, P.K., Jonnalagadda, S., Singh, O.N., McCormick, T.J., Doncel, G.F., Clark, M.R. January 2025

We choose: Adolescent girls and young women’s choice for an HIV prevention product in a cross-over randomized clinical trial conducted in South Africa, Uganda, and Zimbabwe

Atujuna, M., Williams, K., Roberts, S.T., Young, A., Browne, E.N., Mangxilana, N.T., et al. August 2024

Harnessing private sector strategies for family planning to deliver the Dual Prevention Pill, the first multipurpose prevention technology with pre‐exposure prophylaxis, in an expanding HIV prevention landscape

Verde Hashim, C., Llewellyn, E., Wood, R., Brett, T., Chinyanga, T., Webb, K., & Segal, K. August 2024

Dr. Robin Schaefer presents on the future of PrEP

The Forum for Collaborative Research August 2024

Multipurpose Prevention Technologies: Call for Innovative Strategies to Address Critical Priorities and Gaps

Public Health Institute August 2024

Paving the Way for Multi-Purpose Technologies: Programming for Choice and Strengthening Integrated HIV and Sexual and Reproductive Health Services

Rodrigues, J.; Vahle, K.; Mason, J.; Tluway, E.; Buthelezi, B. August 2024

Tailoring drug release from long-acting contraceptive levonorgestrel intrauterine systems

Fanse, S.; Bao, Q.; Zou, Y.; Wang, Y.; Burgess, D.J. August 2024

Summary of the Centers for Disease Control and Prevention/National Institute of Allergy and Infectious Diseases Joint Workshop on Genital Herpes: 3–4 November 2022

Connolly, K.L.; Bachmann, L.; Hiltke, T.; Kersh, E.N.; Newman, L.M.; Wilson, L.; Mena, L.; Deal, C. August 2024

Where’s the Equity? Including People with Disabilities in HIV Prevention Programming and Research

AVAC, Kuper, H., Maseva, T., Minalga, B., Mwikali, S., Davids, J.D., Jeckonia, P. August 2024

Next-Generation Contraceptive Intravaginal Ring: Comparison of Etonogestrel and Ethinyl Estradiol In Vitro and In Vivo Release from 3D-Printed Intravaginal Ring and NuvaRing

Young, I.C.; Thorson, A.L.; Cottrell, M.L.; Sykes, C.; Schauer, A.P.; Sellers, R.S.; Janusziewicz, R.; Vincent, K.L.; Benhabbour, S.R. August 2024

AIDS 2024 Conference by the numbers

Clinton Health Access Initiative August 2024

Developing Live Biotherapeutics for HIV Prevention & MPTs

The IMPT, Douglas Kwon, Jacques Ravel, Anke Hemmerling, Bethany Young Holt July 2024

Service Delivery Preferences for Long-acting Pre-exposure Prophylaxis among Pregnant and Breastfeeding Women in South Africa and Botswana

De Vos, L., Mussa, A., Rousseau, E., et al. July 2024

Injectable long-acting formulations (ILAFs) and manufacturing techniques

Thapa Magar, K.; Boucetta, H.; Zhao, Z.; Xu, Y.; Liu, Z.; & He, W. July 2024

Perception of couples’ on multipurpose prevention technology attribute choice: the case of MTN 045

Dandadzi, A.; Young, A.M.; Musara, P. et al. July 2024

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