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Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya

Globally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective multipurpose prevention technologies. TFV/LNG and TFV-only IVRs were safe and well tolerated among Kenyan women. Pharmacokinetics and markers of protection against HIV-1, HSV-2, and unintended pregnancy suggest the potential for clinical efficacy of the multipurpose TFV/LNG IVR.

June 2023

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Resource Type:

Database
Journal Article
Journal Article
MPT Articles
MPT Article
Resource

Citation:

Globally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective multipurpose prevention technologies. TFV/LNG and TFV-only IVRs were safe and well tolerated among Kenyan women. Pharmacokinetics and markers of protection against HIV-1, HSV-2, and unintended pregnancy suggest the potential for clinical efficacy of the multipurpose TFV/LNG IVR.

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Authors: Mugo, N.R., Mudhune, V., Heffron, R., Thomas, K.K., McLellan-Lemal, E., Njoroge, B., Peacock, S., O’Connor, S.M., Nyagol, B., Ouma, E. and Ridzon, R.

Health Risks(s):

  • HIV
  • Unintended Pregnancy

Product type(s):

  • Contraceptives
  • HIVinhibitor
  • IVR
  • MPTs

Topic(s):

  • DrugInteractions
  • MPTs
  • Trials

Region(s)

  • Africa

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