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Poster abstract: Multipurpose vaginal rings for HIV prevention and non-hormonal contraception

Following recent marketing approval of the dapivirine (DPV)-releasing ring for HIV prevention, efforts are now underway to develop multipurpose ring formulations to simultaneously prevent HIV and unintended pregnancy. Currently, four vaginal hormone- releasing rings offering combination (progestin + estrogen) or progestin-only contraception are available. Given the preference for continuous use of an antiretroviral ring for HIV prevention, it is not surprising that efforts towards multipurpose ring products have focused on incorporation of potent progestins, with levonorgestrel prioritized due to its well- established safety profile. However, hormonal contraceptives are associated with numerous side effects and contraindications, and many women are interested in using hormone-free contraceptive products. Copper (Cu) and zinc (Zn) have well documented spermicidal activity, and various Cu intrauterine devices are marketed and widely used by women. However, to date, there has been very limited research evaluating the potential of vaginal rings containing Cu/Zn for contraception. The aim of this project is to develop a vaginal ring that can provide sustained release of both DPV and Cu/Zn to simultaneously prevent HIV infection and unintended pregnancy.

July 2022

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Database
Journal Article
Journal Article
MPT Articles
MPT Article
Poster
Resource

Citation:

Following recent marketing approval of the dapivirine (DPV)-releasing ring for HIV prevention, efforts are now underway to develop multipurpose ring formulations to simultaneously prevent HIV and unintended pregnancy. Currently, four vaginal hormone- releasing rings offering combination (progestin + estrogen) or progestin-only contraception are available. Given the preference for continuous use of an antiretroviral ring for HIV prevention, it is not surprising that efforts towards multipurpose ring products have focused on incorporation of potent progestins, with levonorgestrel prioritized due to its well- established safety profile. However, hormonal contraceptives are associated with numerous side effects and contraindications, and many women are interested in using hormone-free contraceptive products. Copper (Cu) and zinc (Zn) have well documented spermicidal activity, and various Cu intrauterine devices are marketed and widely used by women. However, to date, there has been very limited research evaluating the potential of vaginal rings containing Cu/Zn for contraception. The aim of this project is to develop a vaginal ring that can provide sustained release of both DPV and Cu/Zn to simultaneously prevent HIV infection and unintended pregnancy.

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Health Risks(s):

  • HIV
  • Unintended Pregnancy

Product type(s):

  • Contraceptives
  • HIVinhibitor
  • IVR
  • MPTs

Topic(s):

  • DrugInteractions
  • MPTs
  • Development

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