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Pharmaceutical implants: from concept to commercialization

The pharmaceutical implant is undoubtedly one of the big breakthroughs in novel drug delivery systems. Development of various implants in recent years confirms the important role of this special dosage form in the treatment of various chronic diseases. Many of the first line medicines and also newly developed therapeutic molecules have limited aqueous solubility and poor bioavailability, which limit oral administration. On the other hand, the chronic nature of many diseases needs long-term (and even lifelong) medication which decreases patient compliance and medication adherence. Apart from the bioavailability of the drug molecules, the pharmacokinetic profile is a vital issue in achieving satisfactory clinical outcomes. The big peak and valley in plasma concentration after administration of traditional dosage forms is a big challenge, especially in specific kinds of diseases like epilepsy, cardiac and those that require anticoagulant therapy. One of the big advantages of implantable drug delivery systems is a sustained release fashion of loaded drug molecules over a long period of time, which improves the pharmacokinetic profile of the medicines and also preserves the plasma concentration of drugs. This unique property of the implant system also decreases drug administration frequency and improves patient adherence to the medication. This chapter focuses on pharmaceutical implant drug delivery and explores various commercially available systems. Also, different polymers which have been used in the formulation of implant systems are introduced. Moreover, different industrial manufacturing methods for implants are explained.

January 2024

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Citation:

The pharmaceutical implant is undoubtedly one of the big breakthroughs in novel drug delivery systems. Development of various implants in recent years confirms the important role of this special dosage form in the treatment of various chronic diseases. Many of the first line medicines and also newly developed therapeutic molecules have limited aqueous solubility and poor bioavailability, which limit oral administration. On the other hand, the chronic nature of many diseases needs long-term (and even lifelong) medication which decreases patient compliance and medication adherence. Apart from the bioavailability of the drug molecules, the pharmacokinetic profile is a vital issue in achieving satisfactory clinical outcomes. The big peak and valley in plasma concentration after administration of traditional dosage forms is a big challenge, especially in specific kinds of diseases like epilepsy, cardiac and those that require anticoagulant therapy. One of the big advantages of implantable drug delivery systems is a sustained release fashion of loaded drug molecules over a long period of time, which improves the pharmacokinetic profile of the medicines and also preserves the plasma concentration of drugs. This unique property of the implant system also decreases drug administration frequency and improves patient adherence to the medication. This chapter focuses on pharmaceutical implant drug delivery and explores various commercially available systems. Also, different polymers which have been used in the formulation of implant systems are introduced. Moreover, different industrial manufacturing methods for implants are explained.

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Authors: Saadat, E.

Health Risks(s):

  • Other

Product type(s):

  • Implants

Topic(s):

  • DrugInteractions
  • Development

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