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Non-Hormonal Approaches to Male Contraception

Technology for non-hormonal male contraception can range from application of biologics (large molecules) such as antibody vaccine and mRNA, vas deferens polymeric injection, or small molecules, including natural products as agonists or antagonists of reproductive tissue protein targets. The mechanism of action for these contraceptive agents is to affect sperm production, sperm function, or sperm transport. One prevailing rationale for pursuing non-hormonal contraceptive agents is the concept of little-to-no side effects. This remains to be seen as research and development into non-hormonal methods have proven difficult over the years and selectively or exclusively targeting reproductive tissue proteins as drug targets are in early stages.

October 2023

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Resource Type:

Database
Journal Article
Journal Article
Resource

Citation:

Technology for non-hormonal male contraception can range from application of biologics (large molecules) such as antibody vaccine and mRNA, vas deferens polymeric injection, or small molecules, including natural products as agonists or antagonists of reproductive tissue protein targets. The mechanism of action for these contraceptive agents is to affect sperm production, sperm function, or sperm transport. One prevailing rationale for pursuing non-hormonal contraceptive agents is the concept of little-to-no side effects. This remains to be seen as research and development into non-hormonal methods have proven difficult over the years and selectively or exclusively targeting reproductive tissue proteins as drug targets are in early stages.

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Authors: Blithe, D.L. and Lee, M.S.

Health Risks(s):

  • Unintended Pregnancy

Product type(s):

  • Contraceptives
  • MaleBC

Topic(s):

  • Development

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