The IMPT serves as the ‘communications and information hub’ for the field of multipurpose prevention technologies (MPTs).
Our resource center features a searchable database, providing you access to global MPT research, technical webinars, trainee and career resources, advocacy tools, and more. Search our resources!
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Dose-ranging pharmacokinetics, safety, and efficacy of a 90-day intravaginal ring delivering islatravir in pigtail macaques
Intravaginal rings (IVRs) are attractive user-controlled delivery systems that can achieve sustained release of compounds for several weeks. We modeled in macaques a three-dimensional (3D)–printed IVR delivering the investigational nucleoside reverse transcriptase translocator inhibitor islatravir (ISL). Three IVRs with 15, 30, or 60 milligrams of ISL were used in 30-day pharmacokinetic and safety studies followed […]
Srinivasan, P., King, J. L., Zhang, J., Young, I. C., Little, D., Cottrell, M. L., Sykes, C., Schauer, A. P., Mitchell, J., Kashuba, A. D. M., García-Lerma, J. G., Benhabbour, S. R., Smith, J. M.
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August 2026
From Insight to Innovation: Integrating User Preferences into MPT Development
This session of the IMPT’s Let’s Talk MPTs webinar series will explore how women’s perspectives can shape the next generation of MPTs. Join us to hear new findings on user experiences with an investigational vaginal film for HIV prevention and contraception, alongside U.S.-based research on preferences for MPT product characteristics. Presenters:Alexandra Minnis, PhD, MPH (RHI […]
Alexandra Minnis, PhD, MPH (RHI International), Nyaradzo Mgodi, MD (University of Zimbabwe–Clinical Trials Research Centre (UZ-CTRC), Ann Gottert, PhD, MPH (Population Council) and the IMPT.
Visit Webinar
July 2026
A snapshot of how U.S. funding cuts impacted HIV care in one county of Kenya: a qualitative case study
Sedlander, E., Lawson, K., Wairimu, N., Werner, K., Mutai, S., Mwai, D., Gandhi, M., Ngure, K.
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July 2026
Beyond Myths: Addressing Real Concerns About Contraception and Future Fertility
Begg, L., Owolabi, O., Polis, C. B.
June 2026
‘ … they just take one pill, so it is easy to use, more convenient … ’: South African health care provider perspectives on a Dual Prevention Pill
The Dual Prevention Pill (DPP) is a daily oral pill containing oral pre-exposure prophylaxis (PrEP) for protection against HIV and a combined oral contraceptive (COC) for the prevention of unintended pregnancy, currently under development. However, little is known about healthcare providers’ (HCPs) perspectives on this potential new multipurpose prevention technology (MPT). A more granular understanding […]
Mathur, S., Tenza, S., Begg, L., Mampuru, L., Bruce, I. V., Moji, M., Ndlovu, N., Reddy, K., Palanee-Phillips, T., Friedland, B. A.
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May 2026
My passion and interest in Multipurpose Prevention Technologies (MPTs)
Featured in the CTI Exchange’s Beginning with the End in Mind series, CAMI Health joins the nuanced conversation surrounding self-care within the sexual and reproductive health domain by highlighting the unique contributions and benefits of multipurpose prevention technologies (MPTs).
Recommendations for Expanding Regulatory Agility and Evidentiary Integrity in Developing Treatments for Rare Diseases
Reagan-Udall Foundation for the Food and Drug Administration (FDA)
April 2026
Safety, acceptability, and adherence to dapivirine vaginal ring and oral pre-exposure prophylaxis for HIV prevention in the second trimester of pregnancy: a multicountry, open-label, phase 3b randomised trial
Mhlanga, F.G., Szydlo, D.W., Mayo, A.J., Bunge, K., Fairlie, L., Nakabiito, C., Musara, P., Mgodi, N.M., Dadabhai, S., Scheckter, R., Anderson, P.L., Marzinke, M.A., Chappell, C., Gadama, L.A., Richardson, B.A., Piper, J.M., Hillier, S.L.
March 2026
Advancing Vaginal Health Products: Addressing BV and STI/HIV Prevention Through Next-Generation MPTs
This session of IMPT’s Let’s Talk MPTs webinar series explores how next-generation multipurpose prevention technologies (MPTs) can integrate BV management with STI/HIV prevention in single, user-controlled products. Bacterial vaginosis (BV) significantly increases vulnerability to HIV and other sexually transmitted infections (STIs), yet remains under-addressed in prevention strategies. Presenters: Ishita Shah, PhD (Matrubials, Inc.) discussed antimicrobial […]
Jen Balkus PhD, MPH (University of Washington | Public Health Seattle & King County), Ishita Shah PhD (Matrubials Inc.), Laurel Lagenaur PhD (Osel Inc.) and the IMPT.
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February 2026
Multipurpose vaginal rings: preferences from a national discrete choice experiment survey among US women
Gottert, A., Mathur, S., Friedland, B.A., Abuya, T., Bruce, I.V., Burnett-Zieman, B., Plagianos, M.G., Shetty, S., Sales, J.M., Haddad, L.B.
February 2026
Strengthening nationally led approaches to new product introduction for HIV prevention
Subedar, H., Ncube, N.B.Q., Kadama, H., Matanje, B., Kamya, M.R., Mugambi, C., Mudiope, P., Ajose, O., Jenkins, S.Y., Roxo, U.C., Pérez Casas, C., Warren, M., Cameron, A., Ismail, A., Odek, J., Gunda, A., Mulenga, L., Ozituosauka, W., Hamm Rush, S., Luba, M., Hoege, D., Sakala, M., Igbinosun, B.O., Burry, J., Allinder, S.M., Holmes, C.B.
January 2026
Sexual and reproductive health in disasters: A systematic review of digital health and multipurpose prevention
Dewantiningrum, J., Andonotopo, W., Pramono, M.B.A., Prabowo, W., Bachnas, M.A., Sanjaya, I.N.H., Wiradnyana, A.A.G.P., Darmawan, E., Akbar, M.I.A., Gumilar, K.E., Aldiansyah, D., Andanaputra, W.E.K., Suryawan, A., Putra, R.A., Stanojeviv, M.
January 2026
HIV prevention for young African women is about choice
Stewart, J., Heffron, R., Celum, C.
January 2026
The Current and Future Impact of WHO Guidance on Global HIV Pre-Exposure Prophylaxis Programs: A Narrative Review
Mishriky, F., Chan, P.A.
January 2026
Bridging HIV prevention and sexual reproductive health services in the context of multi-method PrEP: a qualitative study exploring provider perceptions in South Africa
Musvipwa, F.M., Dada, S., Cholo, F.A., Pleaner, M., Letsielo, M.J., Arries, S., Kutywayo, A., Martin, C.E., Mullick, S.
January 2026
Uptake of dapivirine vaginal ring and oral pre-exposure prophylaxis among women accessing HIV prevention services in South Africa: a cohort study
Martin, C.E., Ramatsoma, H., Chidumwa, G., Nongena, P., Letsielo, M.J., Kutywayo, A., Koloane, N., Ncube, S., Mdluli, N., Nattey, C., Mullick, S.
January 2026
Modern contraception utilization and associated factors among adolescent girls and young women (AGYW) who participated in the Namibia DREAMS program
Moyo, E., Melese, E., Mangwana, H., Takawira, S., Harases, B., Indongo, R., Moyo, P., Makurira Nyoni, N., Dzinamarira, T.
December 2025
Artificial neural network guided optimization of tenofovir and Cyanovirin-N multipurpose preventive hydrogel formulation developed using the Box Behnken design model
Oyediran, K.O., Cardoso-Daodu, I.M., Bassey, P.O., Ogundemuren, D.A., Muhammed, R., Ojo, O.E., Amenaghawon, A.N., Azubuike, C.P., Agarwal, R., Haritha, K., Ilomunaya, M.O.
December 2025
Advances in drug-releasing vaginal rings
McCoy, C.F., Zhao, X., Shen, X., Bashi, Y.H.D., Murphy, D.J., Boyd, P., Malcolm, R.K.
November 2025
A Dual Prevention Pill for HIV & Pregnancy Prevention: A Pilot Study Among Adolescent Girls and Young Women in Zimbabwe
Mgodi, N.M., Burnett-Zieman, J.B., Murombedzi, C., Dandadzi, A., Gatsi, V., Musara, P., Matimbira, S., Mavemwa, G., Jambaya, J., Chidemo, T., Plagianos, M., Haddad, L.B., Bruce, I.V., Mathur, S., Friedland, B.A.
November 2025
Beyond the pill: contextual effects of community-based PrEP delivery on pregnancy risk among FSWs in Cameroon – a propensity score-matched analysis
Noah, J.P.Y.A., Ndongo, F.A., Ndié, J., Bonyohe, M.G., Dongmo, R.K., Komokcheua, R.B., Tabala, F.N., Ateudjieu, J., Bissek, A.C.Z.K.
November 2025
Next Generation 3D Printed Multipurpose Intravaginal Ring For Sustained Co-Delivery of Antiretroviral Drugs and A Contraceptive Hormone
Dahl, D.K., Janusziewicz, R., Shrivastava, R., Maturavongsadit, P., Chan, E., Montgomery, S.A., Benhabbour, S.R.
November 2025
Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them
Herron, T.J., Brüning-Richardson, A., Gough, J.E., Miller, A.F., Pilkington, G.J., Greenman, J., Speirs, V., Wu, J.C.
October 2025
Dual Prevention Pill
PrEPWatch, an Initiative of AVAC.
October 2025
Public-Private Partnerships to Advance MPT Development
Michael Santos (FNIH), The IMPT
September 2025
Introducing the Dual Prevention Pill: Lessons Learned and What’s Next for Regulatory, Research, and Rollout
Kate Segal (AVAC), Wawira Nyagah (AVAC), and Barbara Friedland (Population Council), The IMPT
September 2025
Tenofovir and levonorgestrel vaginal MPT film developed via quality by design approach (drug release and safety evaluation in an animal model)
Muhammad, R., Bassey, P. O., Nwaneri, S. C., Cardoso-Daodu, I. M., Oladosu, A. A., Oyediran, K. O., Ilomuanya, M. O.
September 2025
“…this could be a noble idea and a game changer.” The potential of a dual prevention pill for HIV and pregnancy prevention among adolescent girls and young women in Zimbabwe.
Dandadzi, A., Mathur, S., Musara, P., Bruce, I., Begg, L., Sedze, N. T., Mutero, P., Mgodi, N. M., Friedland, B. A.
August 2025
Evaluating Vaginal MPT Product Performance Using Experimental and Computational Modeling Approaches
The IMPT, Lisa Rohan, Sravan Patal.
August 2025
Predictors Of Dual Protection Use Based On Information-Motivation-Behavior Skill Model Among Female University Students: A Cross-Sectional Study
Feyisa, B. N., Debelew, G. T., Koricha, Z. B.
August 2025
Exploring the Safety and Compatibility of a Ready-to-Use Vaginal Film Vehicle for Drug Delivery: A Clinical Assessment
Marianni, B., Silva, C. C. V., Koulouridas, S., Polonini, H.
August 2025
Unlocking the Potential of MPTs: Funding Trends for MPTs, HIV/STIs, Contraception
The IMPT, Cécile Ventola, Audrey Fratus, Bethany Young Holt
July 2025
Innovative Multilayered Electrospun Fiber Systems for Dual-Action HIV Prophylaxis and Non-hormonal Contraception
Ogundemuren, D. A., Bassey, P.-O. O., Oyediran, K. O., Nmesoma, O. G., Tsamos, D., Tsamis, A., Tsouknidas, A. E.
June 2025
Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects
Sanchez Armengol, E., Veider, F., Millotti, G., Kali, G., Bernkop-Schnürch, A., Laffleur, F.
June 2025
What do women want in pharmacy-based HIV prevention services during pregnancy? Developing attributes and levels for a discrete choice experiment in Western Kenya
Mugambi, M. L., Dollah, A., Ouda, R., Oyugi, N., Odhiambo, B. O., Marwa, M. M., Nyakina, J., Kinuthia, J., Weiner, B. J., John-Stewart, G., Barnabas, R. V., Hauber, B.
June 2025
Vaginally-delivered fast-dissolving antibody tablets (FDAT) for on-demand non-hormonal contraception and multi-purpose protection
Kushiro, K., Hammers, S., Zhu, Y., Flowers, H. B., Dawson, L., Panjwani, A., Schaefer, A., Quan, D., Gibb, K., McSweeney, M., Cone, R., Moench, T., Vincent, K. L., Lai, S. K.
June 2025
Frontiers in Reproductive Health: Regulatory Pathways and Challenges in MPT Development
Donaldson, L., Schaefer, R., Alhakimi, S., Akulu, R., Palanee-Phillips, T., Young Holt B., Miller, V.
May 2025
DoxyPEP in 2026: Who Benefits, How to Prescribe, and What to Watch
Lima, D. B.
April 2025
A multipurpose silicone elastomer vaginal ring releasing dapivirine and Cu2+/Zn2+ ions for HIV prevention and non-hormonal contraception
Shen, X., Boyd, P., Dallal Bashi, Y.H., McCoy, C.F., Zhao, X., Malcolm, R.K.
April 2025
Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis
Vodstrcil, L.A., Plummer, E.L., Fairley, C.K., Hocking, J.S., Law, M.G., Petoumenos, K., Bateson, D., Murray, G.L., Donovan, B., Chow, E.P.F., Chen, M.Y., Kaldor, J., Bradshaw, C.S.
March 2025
Acceptability of an annual tenofovir alafenamide implant for HIV prevention in South African women: findings from the CAPRISA 018 Phase I clinical trial
Gengiah, T.N., Heck, C.J., Lewis, L., Mansoor, L.E., Harkoo, I., Myeni, N., Baum, M.M., Moss, J.A., Rooney, J.F., Hankins, C., Pozzetto, B., Abdool Karim, S.S., Abdool Karim, Q.
February 2025
Advancing Health Solutions: Practical Considerations for Multipurpose Prevention Technologies in Sub-Saharan Africa’s Fight Against HIV, Sexually Transmitted Infections, and Unintended Pregnancies
Mgodi, N.M., Murombedzi, C., Murewanhema, G., Moyo, E., Dzinamarira, T.
January 2025
Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology development
Friedland, B.A., Gundacker, H., Achilles, S.L., Chen, B.A., Hoesley, C., Richardson, B.A., Kelly, C.W., Piper, J., Johnson, S., Devlin, B., Steytler, J., Kleinbeck, K., Dangi, B., Friend, C., Song, M., Mensch, B., van der Straten, A., Jacobson, C., Hendrix, C.W., Brown, J., Blithe, D., Hiller, S.L.
January 2025
Formulation development of dual-compartment topical inserts combining tenofovir alafenamide and elvitegravir for flexible on-demand HIV prevention
Agrahari, V., Peet, M.M., Chandra, N., Ramalingam, P., Gupta, P.K., Jonnalagadda, S., Singh, O.N., McCormick, T.J., Doncel, G.F., Clark, M.R.
January 2025
We choose: Adolescent girls and young women’s choice for an HIV prevention product in a cross-over randomized clinical trial conducted in South Africa, Uganda, and Zimbabwe
Atujuna, M., Williams, K., Roberts, S.T., Young, A., Browne, E.N., Mangxilana, N.T., et al.
August 2024
Harnessing private sector strategies for family planning to deliver the Dual Prevention Pill, the first multipurpose prevention technology with pre‐exposure prophylaxis, in an expanding HIV prevention landscape
Verde Hashim, C., Llewellyn, E., Wood, R., Brett, T., Chinyanga, T., Webb, K., & Segal, K.
August 2024
Dr. Robin Schaefer presents on the future of PrEP
The Forum for Collaborative Research
August 2024
Multipurpose Prevention Technologies: Call for Innovative Strategies to Address Critical Priorities and Gaps
Public Health Institute
August 2024
MPT Trainee Photo Credit: Charmaine Cozzi, Wits RHI