Back to Resource Center

17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, is an effective spermicide and microbicide against Neisseria gonorrhoeae

Is 17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, a better spermicide in cervicovaginal fluid (CVF) than its parental peptides, LL-37 and GF-17? At the same mass concentration, 17BIPHE2 exhibited the highest spermicidal activity on human sperm resuspended in CVF-containing medium.

Since 17BIPHE2 also exerted bactericidal activity against N. gonorrhoeae at its spermicidal concentration, it is a promising candidate to be developed into a vaginal multipurpose prevention technology agent, thus empowering women against unplanned pregnancies and sexually transmitted infections.

September 2022

Click for full info +

Full Info:


Resource Type:

Database
Journal Article
Journal Article
MPT Articles
MPT Article
Resource

Citation:

Is 17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, a better spermicide in cervicovaginal fluid (CVF) than its parental peptides, LL-37 and GF-17? At the same mass concentration, 17BIPHE2 exhibited the highest spermicidal activity on human sperm resuspended in CVF-containing medium.

Since 17BIPHE2 also exerted bactericidal activity against N. gonorrhoeae at its spermicidal concentration, it is a promising candidate to be developed into a vaginal multipurpose prevention technology agent, thus empowering women against unplanned pregnancies and sexually transmitted infections.

View Journal Article

Authors: Lee, S.G., Kiattiburut, W., Khongkha, T., Schinkel, S.C.B., Lunn, Y., Decker, A.P., Mohammadi, A., Vera-Cruz, A., Misra, A., Angel, J.B. and Anderson, D.J.

Health Risks(s):

  • Gonorrhea
  • STI / STD
  • Unintended Pregnancy

Product type(s):

  • Microbicide
  • MPTs
  • Other

Topic(s):

  • DrugInteractions
  • MPTs
  • Development

Back to Resource Center