Articles tagged with: HIV

Oct17

Monoclonal antibodies as future MPT products

Wednesday, 17 October 2018 Written by // Kevin Whaley Series // From the Pipeline Tags // contraceptive, HIV, manufacturing, monoclonal antibodies

Monoclonal antibodies are engineered proteins derived from a single parent cell and have been used in a diverse range of therapeutic applications due to their versatility and specificity. At Mapp Biopharmaceutical, Inc., we believe monoclonal antibodies are promising candidates for multipurpose prevention technologies (MPTs) when formulated as topical (e.g., films and rings) or injectable products. Systemic antibodies may have multiple effector functions – like complement binding (CDC) and binding to monocytes (ADCC) – while mucosal mechanisms agglutination and trapping in mucus are less widely discussed, but are crucial for the protection of mucosal surfaces. Systemically and mucosally delivered antibodies have demonstrated efficacy in SHIV prevention studies. In this post, we describe some of the important progress to date on monoclonal antibodies as future MPTs.

Oct16

Young people are leading the charge of the HIV prevention movement

Tuesday, 16 October 2018 Written by // Erin McKelle Tags // HIV, prevention, young people, youth

HIV prevention has come to the forefront of youth activism and public health advocacy, as young people aged 15-24 account for 35% of new HIV infections worldwide. In fact, as we work to curb the HIV epidemic, they are the only age group to experience a recent increase in HIV infections. Young people are disproportionately impacted by HIV and face unique challenges in protecting their sexual health as they navigate complex biological and social transitions into adulthood. In that spirit, the FDA recently approved PrEP (Pre-Exposure Prophylaxis) for adolescents, which has huge implications for empowering young people to prevent HIV exposure or transmission.

Sep24

Just released: IMPT’s article on advancing MPTs that combine hormonal contraception and HIV prevention

Monday, 24 September 2018 Tags // action framework, contraception, HIV, hormonal, prevention

The field of MPTs that combine hormonal contraception (HC) and antiretroviral drugs for HIV prevention has made substantial progress in the past several years. There are two such MPTs in phase I clinical trials: 1) IPM’s dapivirine and levonorgestrel intravaginal ring and 2) CONRAD’s tenofovir and levonorgestrel intravaginal ring – with several other HC + ARV MPT products on the cusp in various stages of preclinical development.

Jun08

Women around the world lack access to comprehensive contraception—this is the solution

Friday, 08 June 2018 Written by // Bethany Young Holt Tags // contraception, HIV, prevention, product, STIs, women

In the early 1990’s, I met a young woman named Gelete. I was working as part of an HIV prevention team along the Sudanese border of Ethiopia, and Gelete was one of our team’s most committed local volunteers working to implement our condom distribution program. Growing up, she dreamed of becoming a physician and attending medical school—but, at age 16, she was raped by her teacher, became pregnant and was then ostracized and abandoned by her own family. With no support and a baby to feed, she moved to a small town to work on a coffee plantation. Since coffee bean harvesting is seasonal work with few other opportunities available in the off season, Gelete joined other young women in similar situations exchanging money for sex to survive.

Apr19

If you like it, put a ring in it! The intravaginal ring that may soon be a life changer in the sexual and reproductive health arena

Thursday, 19 April 2018 Written by // Everlyne Ombati Tags // contraception, end-user, HIV, reproductive health, SRH, STIs, vaginal ring, women

Yes! Yes! We soon may have a ring for our vaginas! I know what you are thinking; vaginal rings have been here since sliced bread. True, but what’s new about this one is that it will provide protection from HIV. Future rings will also include protection from unintended pregnancies and other sexually transmitted infections (STIs), too. And when that ring is available, I am putting it in! Because I like my vagina, and I want to stay healthy.

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